منابع مشابه
Association of candesartan vs losartan with all-cause mortality in patients with heart failure.
CONTEXT Angiotensin II receptor blockers (ARBs) reduce combined mortality and hospitalization in patients with heart failure (HF) with reduced left ventricular ejection fraction. Different agents have different affinity for the AT(1) receptor and may have different clinical effects, but have not been tested against each other in HF. OBJECTIVE To assess the association of candesartan vs losart...
متن کاملComparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man.
The angiotensin II antagonistic effects of candesartan and losartan were compared in-vivo after single and repeated doses. Effects were related to antagonistic activity in plasma. In this double-blind, crossover study, 12 healthy male volunteers received, in random order, daily oral doses of 8 mg candesartan cilexetil or 50 mg losartan for seven days. On day 1 and day 8, dynamics and kinetics w...
متن کاملCandesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats
Minimal hepatic encephalopathy is more common than the acute syndrome. Losartan, the first angiotensin-II receptor blocker (ARB), and candesartan, another widely-used ARB, have protected against developing fibrogenesis, but there is no clear data about their curative antifibrotic effects. The current study was designed to examine their effects in an already-established model of hepatic fibrosis...
متن کاملCost-effectiveness of candesartan versus losartan in the primary preventive treatment of hypertension
BACKGROUND Although angiotensin receptor blockers have different receptor binding properties, no comparative randomized studies with cardiovascular event endpoints have been performed for this class of drugs. The aim of this study was to assess the long-term cost-effectiveness of candesartan (Atacand(®)) versus generic losartan in the primary preventive treatment of hypertension. METHODS A de...
متن کاملComparison of the AT1-receptor blockers candesartan, irbesartan and losartan for inhibiting renal microvascular constriction.
Angiotensin II (Ang II) type 1 (AT1) receptor blockers differ in their affinity for the AT1-receptor, suggesting a dissimilar potency for inhibiting Ang II-induced vascular constriction. In the present study, we compared the effects of candesartan, irbesartan and losartan on the renal microvascular constriction to locally-formed Ang II, using isolated, perfused hydronephrotic rat kidneys. Addit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 1998
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1000616